There is still much that is unknown about how a person develops Long COVID and about how best to treat the condition. 

The Canadian Guidelines for Post COVID-19 Condition (CAN-PCC) has conducted a rigorous review of scientific evidence available for the treatment of Long COVID. They reviewed the evidence for the following medication treatments. Each treatment is discussed in this section, including what the evidence says and what the CAN-PCC recommends based on evidence available. 

The recommendations are up to date as of Spring 2025. Please note many of these medications are not currently recommended by the CAN-PCC, based on research evidence of their safety and benefits. 

If a treatment is not recommended by CAN-PCC or another guideline committee, it does not always mean that it will not be helpful for you. The decision should be based on guidelines, available evidence on the risks and benefits of the treatment, your provider's clinical experience, and taking your symptoms, preferences and values into account.

​

As more research evidence and new treatments become available these recommendations may change. Please go to the CAN-PCC website for more information about these guidelines. Each recommendation is offered in both technical and plain language format.